Muscle-Tropic Capsids for Gene Transfer
November 30, 2021 | Terry Sharrer
“Here, we [scientists at the Broad Institute-MIT/Harvard] developed the DELIVER (directed evolution of AAV capsids leveraging in vivo expression of transgene RNA) strategy to combine diverse capsid library generation with stringent transcript-based in vivo selection and to enable directed evolution followed by identification of functional capsid variants in any tissue of interest and any animal model. . . . Overall, our muscle-directed vectors demonstrate superior potency and selectivity for transduction of both skeletal muscle and cardiac tissue when compared to AAV9 and AAVrh74.” MORE
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