POSTS TAGGED AS Broad Institute

SHERLOCK for RNA Editing

CRISPR-Cas13 editing could offer new avenues for treatment
Scientists at the Broad Institute, who were involved in the technology of CRISPR [MORE]

Migraine, Heart Disease, and Hypertension: Three Ailments for the Price of One Gene

Broad scientists show how 1 bad gene takes a toll on 5 vascular diseases
Immunologists, among others, know that a single [MORE]

Single Cell Atlas for Defining Disease

Single Cell Atlas for Defining Disease
“Here, we [researchers at the Broad Institute and collaborators] applied four single-nucleus RNA sequencing methods [MORE]

Gene Editing for DNA Repair

Enhanced prime editing systems
“Toward the goal of enabling a wide range of sequence changes, we [a collaboration of Broad Institute, [MORE]

Another Gene Editing System

New Gene Editing Proteins Found Outside of CRISPR Systems
“Scientists at MIT’s McGovern Institute and the Broad Institute of MIT and [MORE]

Muscle-Tropic Capsids for Gene Transfer

Graphical abstract
“Here, we [scientists at the Broad Institute-MIT/Harvard] developed the DELIVER (directed evolution of AAV capsids leveraging in vivo expression [MORE]

SEND (Selective Endogenous eNcapsidation for Cellular Delivery)

mRNA gene therapy with a human protein
For a generation, gene therapy has relied on viral vectors to deliver a transgene.  [MORE]

World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants to Human Health and Disease

Genebass resource linking protein-coding variants to health and disease
“Genebass [sic] is a resource of exome-based association statistics, made available to [MORE]

A COVID-19 Biobank

COVID-19
Last February, when more than 100 Biogen representatives from around the world attended a conference, they unwittingly became a means [MORE]

Repurposing Drugs against Cancer

Repurposed medications
MAIN does not ordinarily carry drug-related news, but in this case, repurposing existing drugs to previously unknown targets really [MORE]

A Neonate Genetic Screen for Lifelong Obesity Risk

Polygenic score to predict obesity risk
Researchers at the Broad Institute have developed a polygenic test that could be given to [MORE]

Multigene Test for High Risk Heart Disease, et al

DNA Multigenic risk score
Polygenic risk scores may become as routine as cholesterol screening. To that end, researchers at the Broad [MORE]

Cell Atlas of the Small Intestine

Small Intestine Cellular Composition
Quoting directly: “The lining or epithelium of the gut is one of the body’s most diverse and [MORE]

Reversible RNA Editing

The Broad Institute’s pioneering lab for gene editing has developed a version of CRISPR that permits reversible RNA editing. “The [MORE]