POSTS TAGGED AS Broad Institute

Polygenic Risk Scores for 10 Diseases

Polygenic risk scores for 10 diseases
“From an initial list of 23 conditions, ten were selected for implementation based on PRS [MORE]

Priming Liquid Biopsies

Novel priming strategy boosts liquid biopsy sensitivity
“A team of researchers from MIT and the Broad Institute of MIT and Harvard [MORE]

Bacterial System for Protein Delivery

Scientists find ‘ultracool’ tiny needle that could someday deliver gene editing therapies
“Gene editing has been limited to a few sites [MORE]

SHERLOCK for RNA Editing

CRISPR-Cas13 editing could offer new avenues for treatment
Scientists at the Broad Institute, who were involved in the technology of CRISPR [MORE]

Migraine, Heart Disease, and Hypertension: Three Ailments for the Price of One Gene

Broad scientists show how 1 bad gene takes a toll on 5 vascular diseases
Immunologists, among others, know that a single [MORE]

Single Cell Atlas for Defining Disease

Single Cell Atlas for Defining Disease
“Here, we [researchers at the Broad Institute and collaborators] applied four single-nucleus RNA sequencing methods [MORE]

Gene Editing for DNA Repair

Enhanced prime editing systems
“Toward the goal of enabling a wide range of sequence changes, we [a collaboration of Broad Institute, [MORE]

Another Gene Editing System

New Gene Editing Proteins Found Outside of CRISPR Systems
“Scientists at MIT’s McGovern Institute and the Broad Institute of MIT and [MORE]

Muscle-Tropic Capsids for Gene Transfer

Graphical abstract
“Here, we [scientists at the Broad Institute-MIT/Harvard] developed the DELIVER (directed evolution of AAV capsids leveraging in vivo expression [MORE]

SEND (Selective Endogenous eNcapsidation for Cellular Delivery)

mRNA gene therapy with a human protein
For a generation, gene therapy has relied on viral vectors to deliver a transgene.  [MORE]

World’s Largest Browsable Resource Linking Rare Protein-Coding Genetic Variants to Human Health and Disease

Genebass resource linking protein-coding variants to health and disease
“Genebass [sic] is a resource of exome-based association statistics, made available to [MORE]

A COVID-19 Biobank

COVID-19
Last February, when more than 100 Biogen representatives from around the world attended a conference, they unwittingly became a means [MORE]

Repurposing Drugs against Cancer

Repurposed medications
MAIN does not ordinarily carry drug-related news, but in this case, repurposing existing drugs to previously unknown targets really [MORE]

A Neonate Genetic Screen for Lifelong Obesity Risk

Polygenic score to predict obesity risk
Researchers at the Broad Institute have developed a polygenic test that could be given to [MORE]