Personalized Knee Replacement
Personalised high tibial osteotomy
“The aim of this study was to investigate the safety of the new personalised treatment [for tibial [MORE]
Gene Editing for Cystic Fibrosis
Evaluating CRISPR-based prime editing for cancer modeling
“Prime editing is a recently reported genome editing tool using a nickase-cas9 fused to [MORE]
Glycopolymer Coating to Prevent Organ Rejection
Drs. Siren and Kizhakkedathu in the lab at UBC’s Centre for Blood Research
From the University of British Columbia: “Researchers have [MORE]
Bladder on a Chip and Bladder Organoids
Bladder-on-a-chip and organoids reveal dynamics or UTIs
“Researchers at the Ecole Polytechnique Fédérale de Lausanne in Switzerland developed two complementary benchtop [MORE]
Cultured Tissue: Mimicking a Beating Heart
Heart Model Simulates Mechanical Load on Cardiac Tissues
“Researchers at Carnegie Mellon University, along with collaborators in the Netherlands, have developed [MORE]
First in vivo Use of CRISPR-Cas9 in a Human
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
“Transthyretin amyloidosis . . . is a life-threatening disease characterized by progressive accumulation [MORE]
Electric Patch Hastens Bone Healing
Self-powered biodegradable patch zaps broken bones to heal them
University of Wisconsin-Madison engineers have developed an electrical patch called a fracture [MORE]
Roboworm
Light-responsive nematode worms
As this piece admits, “biomedical applications may be too far away to envision” (though perhaps not for MAIN’s [MORE]
A COVID-19 and Variants Environmental Biosensor
Soterius Scout sensor detects even asymptomatic COVID-19
“Reliable, accurate and non-invasive, the Soterius Scout sensor can deliver results within a minute [MORE]
Lab Space Architecture and Design
Research facility design
Many if not most of MAIN’s readers work in scientific laboratories, where researchers likely had little input into [MORE]
Visualizing Metabolism
Metabolic Processes Visualized at the Single-Cell Level
“Researchers at the University of Chicago’s Pritzker School of Molecular Engineering and Biological Sciences [MORE]
A Dissolvable Pacemaker
Transient pacemaker dissolves in the body after use
“In a breakthrough that could greatly ease the burden for patients recovering from [MORE]
Spray-On Hydrogel to Protect Organs after Surgery
Spray-On Hydrogel to Prevent Post-Surgery Adhesions
“Researchers at University of California San Diego have developed a spray-on hydrogel that forms a [MORE]
Human Hearing the Ultrasonic
Superhuman spatial hearing technology for ultrasonic frequencies
From acoustic engineers at Aalto University (Espoo, Finland): “we describe a method whereby an [MORE]
Mechanical Stimulation influences Organoid Growth
Mechanical plasticity of collagen in mammary gland organoids
In both organ and tumor growth, chemical and mechanical signaling interact. In this [MORE]
What We Have in Common with Slime Molds
Mechanosensation mediates decisions in aneural organism
Physarum polycephalum, an acellular slime mold, does not have a brain, but is capable of [MORE]
Building a Virus Trap
Engineering a virus trap
From the Technical University of Munich: “DNA molecules can be folded into two- and three-dimensional structures. Binding [MORE]
A Blood Filter for Tumor Cells
Inexpensive filter captures tumor
“Researchers at Kumamoto University in Japan have designed an inexpensive and convenient filter that can isolate circulating [MORE]
An Oral Pacemaker-Like Device for Swallowing
Pacemaker-like devices could restore oral function
“In a new study, researchers at Texas A&M University have delineated the minimum size of [MORE]
CRISPR-Act 3.0
Plant scientists develop a new viable CRISPR for genome engineering
Plant scientists at the University of Maryland describe a gene enhancement [MORE]
Reactivating the p53 Tumor Suppressor Gene
Cancer immunotherapy reactivates tumor suppressor protein
MAIN rarely covers drug discovery, which is a huge field in itself, but this piece [MORE]
Advances in Kidney Organoids
Patterned kidney organoids
“Current kidney organoids model development and diseases of the nephron but not the contiguous epithelial network of the [MORE]
Algorithms for Automated Primary Diagnosis of Digital Pathology Images
Digital pathology
“Digital pathology is poised to take a great leap forward. Within as few as 12 months, image analysis algorithms [MORE]
A Stent with “Spines” for Drug Delivery
Kirigami stent
“Researchers at MIT have developed a kirigami-style stent that can provide localized drug delivery through needle-like projections that pop [MORE]
Gene Transfer with an Optic Adeno-Associated Viral Vector
Design and mode of function of the light-controlled viral transduction system
German and Chinese bioengineers have used “an adeno-associated viral (AAV) [MORE]