Safer Viral Vectors
August 3, 2021 | Terry Sharrer
A bioengineering team at Harvard “has developed a way to “cloak” AAVs [adeno-associated viral vectors] from immune surveillance by inhibiting the activation of a DNA-sensing protein called Toll-like receptor 9 (TLR9). The engineered vectors elicited significantly reduced inflammation and T-cell responses while at the same time improving gene expression in mouse and pig models. . . “ MORE
Image Credit: FierceBiotech.com and Wyss Institute