Exosomes in Transplanted Organ Rejection

A New Era in Post-Transplant Monitoring
“Of particular relevance to kidney transplant monitoring are the exosomes excreted in urine, which have high concentrations of mRNA derived from T cells. Urine has long been known as a valuable source of molecules serving as diagnostic markers for renal disease, and urinary exosomes have been shown to be effective screening tools for kidney allograft rejection. A proprietary exosomal mRNA signature developed by ExosomesDx discriminated between biopsy samples from patients with all-cause rejection and those with no rejection (9). The assay also differentiated acute TCMR from ABMR in kidney transplant recipients, showcasing the ability of exosomal multigene signatures to support more personalized patient management. Given their reliability and stability, urinary exosomal assays could represent a less invasive and burdensome approach to monitor graft health and potentially open the door for at-home collections.” MORE
Image Credit: AACC