Myogenic tissue nanotransfection improves muscle torque recovery following following VLM

“This research work tests tissue nanotransfection (TNT) based gene therapy as an acellular treatment for VML, with the goal of overexpressing MyoD to affect cells in the fibrotic region towards improved functional rescue of the affected muscle. Fibroblasts, abundant in the fibrotic defect, are known for their inherent plasticity and are known to readily convert into myogenic cells in response to MyoD delivery. To eliminate risks associated with viral gene delivery, the electrophoretic TNT approach was adopted.” MORE

Image Credit:  Nature.com