Nanopore Sequencing
November 3, 2009 | Terry Sharrer
DNA sequencing typically requires restriction enzymes to chop up segments and then fluorescent dye labeling so the reader can detect bases as they pass by. IBM, however, believes it is simpler to electrically drive unchopped sequences through a nanopore-arrayed chip where software can calculate the bases according to their electrical and physical properties. In effect, nanopore sequencing is the tiniest electrophoresis device hooked to a supercomputer. MORE