Methylation of the Brain’s Residential Immune Cells
March 15, 2022 | Terry Sharrer
From neuroscientists at the Icahn School of Medicine at Mt. Sinai: “We found that human microglial cells have a methylation profile distinct from bulk brain tissue and neurons, and age explained a considerable part of the variation. Additionally, we showed that interindividual factors had a much larger effect on the methylation landscape of microglia than brain region that was also seen at the transcriptome level. In our explorative analysis we found various differentially methylated regions (DMRs) that were related to disease status (mood disorder versus control). This included DMRs that are linked to gene expression in microglia, as well as to myeloid cell function or neuropsychiatric disorders.” MORE
Image Credit: 3Hbiomedical.com