Peroxisome Development Disorders
“Peroxisomes are single-membrane enclosed eukaryotic organelles playing central roles in lipid metabolism and maintenance of redox balance. Impaired peroxisomal assembly and/or defects in reactive pathways housed by peroxisomes manifest in severe metabolic disorders. There is also increasing evidence correlating peroxisomal dysfunction with aging and a broad range of relevant diseases, including cancer, Parkinson’s disease and diabetes. Peroxisomal enzymes are produced in the cytosol and then imported into the peroxisomal matrix10. The majority of peroxisomal matrix enzymes carry a C-terminal Peroxisome Targeting Signal (PTS1), which is recognized by the peroxisomal receptor Pex5 in the cytosol. Pex5 delivers its cargo to a docking complex at the peroxisomal membrane. This interaction triggers the formation of a transient nuclear-pore like assembly.” MORE
Image Credit: Nature