Lymphatic Capillaries in Intestinal Regeneration

Lymphatic capillaries in intestinal regeneration
“This study found that stem cells integrate cues from their surroundings to coordinate their behavior across the tissue through networks of nearby vasculature, and their activity is regulated by lymphatic capillaries . . . . When the stem cells renew, they remain in what is called a ‘crypt’, which is found at the base of densely packed indentations in the intestinal lining. . . . . To study these crypts in more detail and identify cell types and signaling molecules at specific locations, the researchers [Rockefeller University] used a variety of techniques including single-cell and spatial transcriptomics. They found that lymphatic capillaries have connections with stem cells in the crypt and produce proteins that are known to be important for stem cell functioning. One of the proteins identified called REELIN had previously been overlooked, the researchers explained.” MORE
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