Human brain organoid

“. . . [A] stem cell biologist at the University of California, San Francisco, and his team demonstrate that human brain organoids don’t accurately recapitulate all aspects of development. After comparing cells from organoids to those from normally developing tissue, his team reports that organoids have altered gene expression patterns and lack the cellular diversity found in the human brain.”  This may happen because of growing on a flat surface rather than in a three-dimensional shape, and the same situation may occur with stem cells of other organs.   MORE

Image Credit: Madeline Andrews, UCSF