Problems in Stem Cell Genetics
February 22, 2011 | Terry Sharrer
Researchers at the University of California, San Diego and the Scripps Research Institute recently made a disturbing discovery about stem cells-both embryonic and induced. They found that in tissue culture, human embryonic stem cells showed a higher frequency of copy number duplications, while the induced pluripotent stem cells had more deletions, compared to nonpluripotent lines. Apparently, both occurred more often over time, raising questions about clinical safety and the frequency of monitoring. MORE