Digital DNA detection

First, affix a piece of graphene to a pyrene substrate.  Then, load Cas9 and guide RNA molecules onto the graphene.  When a purified, unamplified sample of DNA is inserted into this transistor, an electrical current activates the binding between the relevant sequence and the RNA, and a change in electrical current registers the match.  This is how a researcher at the Keck Graduate Institute (Claremont, CA) developed a “CRISPR-Chip.”    MORE

Image Credit:  The Scientist and Keck Graduate Institute