Synthetic Double-Stranded RNA for the Treatment of Pancreatic Ductal Adenocarcinoma
” Researchers at Virginia Commonwealth University have discovered a new way of using a synthetic double-stranded RNA for the treatment of pancreatic ductal adenocarcinoma (PDAC), an aggressive type of pancreatic cancer. . . . Pancreatic cancer is commonly diagnosed at a late stage because symptoms only appear once the disease has progressed, and there is still a lack of early detection methods. . . . In their preclinical study published in the Journal for ImmunoTherapy of Cancer, the researchers deployed a new way of delivering polyinosine-polycytidylic acid (pIC)—a synthetic double-stranded RNA—directly into the tumor cell. “In studying this phenomenon in mice with an intact immune system, we found that it worked exceptionally well in PDAC, extending life to an amazing degree just on its own… Nothing like this has been seen before . . . . “ MORE
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