Embedded Nano-Sensor in Cardio Stem Cells
June 20, 2023 | Terry Sharrer
![](http://www.medicalautomation.org/wp-content/uploads/2023/06/Tissue-embedded-stretchable-nanoelectronics-reveal-endothelial-cell–mediated-electrical-maturation-of-human-3D-cardiac-microtissues-JUNE-20.jpeg)
Tissue-embedded stretchable nanoelectronics reveal endothelial cell–mediated electrical maturation of human 3D cardiac microtissues
“Generation of electrically matured human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) is critical for electrical integration. Here, we [at Harvard University] found that hiPSC-derived endothelial cells (hiPSC-ECs) promoted the expression of selected maturation markers in hiPSC-CMs. Using tissue-embedded stretchable mesh nanoelectronics, we achieved a long-term stable map of human three-dimensional (3D) cardiac microtissue electrical activity. The results revealed that hiPSC-ECs accelerated the electrical maturation of hiPSC-CMs in 3D cardiac microtissues. MORE
Image Credit: Science.org