Automating Detection of Micronuclei

Micronuclei, cancer markers counted automatically with new computer program
“Normally, micronuclei are produced by segregation errors and mechanical stresses arising from dividing or migrating cells, leading to activation of the innate immune response pathway. . . . Here, we [scientists at Japan’s University of Tsukuba] introduce a novel MATLAB-based program for quantifying micronuclei (CAMDi: calculating automatic micronuclei distinction) in vitro and in vivo. CAMDi is adaptable to various experimental imaging techniques and is useful for obtaining reproducible data. CAMDi enables us to measure the accurate size of micronuclei from the three-dimensional images. Using CAMDi, we revealed a novel link between the emergence of micronuclei and neuroinflammation.” MORE
Image Credit: Kateryna Kon/Shutterstock and University of Tsukuba Research News