NTU Scientists apply temporal pressure to deliver drugs

Biomedical engineers in Singapore report this: “Tapping on established studies where magnets are used to mimic pressure ulcer injury in vivo due to its well-defined magnetic field and force, this study chose neodymium magnets as the proof-of-concept tool to produce the required pressure force to induce temporal skin barrier changes for drug delivery. Specifically, a local pressure (0.14, 0.28, and 0.4 MPa) is generated by applying two neodymium magnets to pinch skin. After a given time, the magnets are removed, and therapeutics in the moisturizer are topically applied to the pressure-processed area. Here, we report the successful delivery of nanoparticles (NPs; up to 500 nm), dextran molecules (up to 20 kDa), and insulin across the skin of mice.”  MORE

Image Credit:  NTU Media Releases