Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy (aka SLAM)
University of Illinois scientists have developed this microscopy system which uses precise light pulses to simultaneously produce images from multiple wavelengths. And, this can be done with living tissue, even inside the body. Among other things in cancer applications “The researchers saw that the cells near the tumor had differences in metabolism and morphology, indicating that the cells had been recruited by the cancer. In addition, they observed surrounding tissues creating infrastructure to support the tumor, such as collagen and blood vessels. They also saw communication between the tumor cells and the surrounding cells in the form of vesicles, tiny transport packages released by cells and absorbed by other cells.” In effect, they imaged metabolism. MORE WITH VIDEO
Image Credit: Stephen Boppart, University of Illinois