Molecular Trigger for Drug Delivery
July 4, 2017 | Terry Sharrer
Quoting directly from the abstract of this piece, “. . . here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.” Researchers in Canada and Italy collaborated on this work. MORE