A Really Smart Biosensor Chip
May 25, 2010 | Terry Sharrer
Protein scientists in Germany and Japan have developed a new biochip that can detect proteins for specific diseases and show how detected proteins have been modified by disease or chemotherapy. The chip has negatively charged sequences of synthesized DNA in an aqueous salt solution attached to a gold substrate. The unattached end has a fluorescent marker and a capture probe, and an alternating electrical current causes the strand to wave back and forth. If the capture probe connects with its protein target, the strand moves slower (depending on the size and shape of the protein). Computation then analyzes the movement for precise identification and modification. MORE