Hybrid Nanoparticle for Treating Rheumatoid Arthritis
“The new platform developed by Koo (Seoul National University) and colleagues involves immobilizing ceria nanoparticles onto mesenchymal stem cell-derived nanovesicles. Both of these components can hinder different pathogenic factors, allowing them to work individually, but also cooperatively. Ce NPs (ceria is an oxide of a rare earth metal) can scavenge the overproduced ROS in RA-inflicted knee joints. They also induce polarization of M1 macrophages into M2, achieving immediate relief of inflammation and symptoms. MSCNVs deliver immunomodulatory cytokines, which turn dendritic cells (DC) into tolerogenic dendritic cells (tDCs). This generates regulatory T cells for long-term immune tolerance. The combination of both parts in the Ce-MSCNV nanoparticles aims to bridge both innate and adaptive immunity to achieve both short-term pain relief, as well as convert the tissue environment into an immune-tolerant state to prevent the recurrence of symptoms.” MORE
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