Lab-grown mini brains for neurodegenerative disease

Neuroscientists at the University of Cambridge report “the development of a cerebral organoid slice model derived from human induced pluripotent stem cells (iPSCs) that recapitulates mature cortical architecture and displays early molecular pathology of C9ORF72 ALS/FTD. Using a combination of single-cell RNA sequencing and biological assays, we reveal distinct transcriptional, proteostasis and DNA repair disturbances in astroglia and neurons.”  MORE

Image Credit:  University of Cambridge Research News