Modeling ALS w/Frontotemporal Dementia in a Brain Organoid
December 21, 2021 | Terry Sharrer
![](http://www.medicalautomation.org/wp-content/uploads/2021/12/Lab-grown-mini-brains-for-neurodegenerative-disease-Dec-21-300x146.jpeg)
Lab-grown mini brains for neurodegenerative disease
Neuroscientists at the University of Cambridge report “the development of a cerebral organoid slice model derived from human induced pluripotent stem cells (iPSCs) that recapitulates mature cortical architecture and displays early molecular pathology of C9ORF72 ALS/FTD. Using a combination of single-cell RNA sequencing and biological assays, we reveal distinct transcriptional, proteostasis and DNA repair disturbances in astroglia and neurons.” MORE
Image Credit: University of Cambridge Research News