Neuron targeted using SATI

“Salk Institute Researchers have added to the gene-editing toolbox through their novel technique known as intercellular linearized Single homology Arm donor mediated intron-Targeting Integration, or SATI for short. . . .  The novel technique is a knock-in method that can target specific mutated genes in vivo. A normal copy of the problematic gene is inserted into the non-coding region of the DNA before the mutation site. The new gene is then integrated into the genome alongside the mutated gene via DNA repair pathways. As a result, the organism is relieved of the detrimental effects of the mutated gene but does not run the risk of additional adverse effects incurred by fully replacing it.”  MORE

Image Credit:  Salk Institute