Vitamin A in Determining Stem Cell Lineage
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Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices
“In this work, we [researchers with the Howard Hughes Medical Institute at Rockefeller University] found that local vitamin A metabolism acts as a potent upstream regulator of this state during skin re-epithelialization. In applying this knowledge to different settings, we learned that stem cells rely on atRA availability as an essential niche component to balance their contributions to distinct fate choices and lineages during homeostasis and repair. We also defined the minimal requirements needed to produce a suite of skin and hair cell types outside the body, offering potential opportunities to study their biology uncomplicated by the many variables still unaccounted for in the in vivo microenvironment. Given the widespread occurrence of lineage plasticity in normal tissues as well as nonhealing wounds and cancer, these findings may have substantial implications for a variety of applications in regenerative medicine.” MORE
Image Credit: Science