Light-activated molecular machines get cells ‘talking’

“Rice University scientists have used light-activated molecular machines to trigger intercellular calcium wave signals, revealing a powerful new strategy for controlling cellular activity, according to a new study published in Nature Nanotechnology. This technology could lead to improved treatments for people with heart problems, digestive issues and more. . . . .  Scientists used small-molecule-based actuators that rotate when stimulated by visible light to induce a calcium-signaling response in smooth muscle cells. . . .  Cellular response varied based on the type and intensity of the mechanical stimulation: Fast, unidirectionally rotating molecular machines elicited intercellular calcium wave signals, while slower speeds and multidirectional rotation did not.”   MORE

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