Tumor Exosomes
“Evidence suggests that exosomes play an important role in angiogenesis. Myeloid leukemia-derived exosomes regulate angiogenesis through the enrichment of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Skin cancer cells secrete exosomes that deliver EGFR to endothelial cells and promote angiogenesis. Moreover, certain tumor-derived exosomes can drive the secretion of pro-angiogenic cytokines, including FGF, G-CSF, TNF-α, VEGF, and more6. Among them, VEGF-A, a member of the VEGF family, plays a key role in tumor angiogenesis. Other members of this family, which include VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PlGF, show affinity to VEGFR. Except for PlGF, other members play important roles in the process of angiogenesis, thereby promoting cancer progression. Sino Biological has developed a comprehensive collection of cytokines and corresponding receptors associated with angiogenesis, which have been validated to be of high purity and activity.” MORE
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