Direct Methylation Sequencing
August 29, 2023 | Jane Fruchtnicht
“5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. . . . Researchers [at Penn Medicine] have now reported a new kind of DNA sequencing technique that reveals 5-methylcytosine (5mC) tags, which can control gene expression and are thought to have a significant influence on health and disease. Now, clinicians will be able to analyze these tags with very small samples, and without harming the sample used in the assay, so it can still be used in biopsies and other tests. This method, which has been called Direct Methylation Sequencing (DM-Seq), can distinguish 5mC tags from other markers as well.” MORE WITH VIDEO
Image Credit: Research Gate