Novel patient-derived parathyroid organoid developed

“Researchers at the University Medical Center Groningen (Netherlands) led by Robert Coppes and Schelto Kruijff have developed the first ever patient-derived parathyroid organoid (PTO). The authors believe that their research will enable more accurate in vitro testing for drug development and opens the door to a potential hypoparathyroidism treatment. The current study demonstrates that PTOs developed from parathyroid stem cells can accurately model human parathyroid tissue structure and functionality.  . . . .    In this study, the team obtained human benign hyperplastic parathyroid tissue from two surgical patients and isolated parathyroid stem cells by observing self-renewal in single cells. They subsequently cultured these cells to recapitulate parathyroid differentiation to form differentiated patient-derived parathyroid organoids (dPTOs) before testing to demonstrate their comparability to the original human tissue.”      MORE

Image Credit:  Biotechniques.com