Nicotinamide Adenine Dinucleotide (NAD+) Deficiency in Kidney Disease
June 20, 2023 | Terry Sharrer
“Here we [renal scientists at the University of Pennsylvania] show that nicotinamide adenine dinucleotide (NAD+) deficiency drives mitochondrial dysfunction causing inflammation and kidney disease development. Using unbiased global metabolomics in healthy and diseased human kidneys, we identify NAD+ deficiency as a disease signature. Furthermore using models of cisplatin- or ischemia-reperfusion induced kidney injury in male mice we observed NAD+ depletion Supplemental nicotinamide riboside or nicotinamide mononucleotide restores NAD+ levels and improved kidney function.” MORE
Image Credit: Nature Metablism