Regulating Pluripotency
June 7, 2022 | Terry Sharrer
From research at the Babraham Institute, a partner organization of Cambridge University: “we use genome-wide screening to identify essential regulators as well as major impediments of human primed to naïve pluripotent stem cell reprogramming. We discover that factors essential for cell state change do not typically undergo changes at the level of gene expression but rather are repurposed with new functions. Mechanistically, we establish that the variant Polycomb complex PRC1.3 and PRDM14 jointly repress developmental and gene regulatory factors to ensure naïve cell reprogramming.” MORE
Image Credit: Science.org