Automated High Throughput Screening
August 22, 2017 | Terry Sharrer
Modern drug discovery fundamentally depends on two processes: combinatorial chemistry and high throughput screening. Bruce Merrifield (1963) and Mario Geysen (1984) pioneered the technology for assembling massive arrays of peptides in combinatorial chemistry, and since then robotics, computer science and engineering have pushed high throughput screening from 1,000 compounds a day to ultra-high throughput of over 100,000 per day. This piece describes a microplate-free approach that relies on acoustic liquid handling technology for screening. MORE WITH VIDEO
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