Closed-Loop Anesthesia Delivery [CLAD]
January 2, 2024 | Terry Sharrer
From the Picower Institute at MIT: “By combining neurophysiology, real-time signal processing, control theory with a programmable infusion pump system, we implemented a nonhuman primate (NHP) CLAD system that controls unconsciousness with the anesthetic propofol. Our CLAD system accurately and reliably controlled unconsciousness along different trajectories for nearly 19 h in nine experiments in two NHPs. Our findings establish critical steps for human testing of CLAD systems.” MORE
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