Ultrasound Implantable Allows Passage of the BBB
August 22, 2023 | Terry Sharrer
“Researchers at Northwestern University have trialed an implanted ultrasound device in patients, which is used in combination with microbubbles to transiently open pores in the blood brain barrier, allowing chemo drugs to enter. We have reported on this technique before as a lab-based concept, but this is the first time that it has actually been trialed in human patients, in this case patients with glioblastoma, a difficult to treat brain cancer. The approach successfully led to a four- to six-fold increase in chemo concentrations in the brain, using drugs that are not otherwise able to cross the blood-brain barrier, sparking hopes that the technique could pave the way for an effective treatment.” MORE
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