Microparticle Therapy Effective for Multiple Sclerosis
August 15, 2023 | Terry Sharrer
“To target, engage, and activate myelin-specific Tregs, we [biomedical engineers, Johns Hopkins University Medical School] designed a biodegradable microparticle (MP) loaded with rapamycin and functionalized with a biased interleukin-2 (IL-2) fusion protein and a major histocompatibility complex (MHC) class II loaded with a myelin peptide. These tolerogenic MPs (Tol-MPs) were validated in vitro and then evaluated in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Tol-MPs promoted sustained disease reversal in 100% of mice and full recovery in 38% of mice with symptomatic EAE. Tol-MPs are a promising platform for treatment of autoimmune diseases.” MORE
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