Sum Share – EHR

Pleiotropy analysis aims to discover how single genes can have different expressions.  In this piece, researchers at Penn Medicine (University of Pennsylvania) “. . . introduce Sum-Share, a method designed to efficiently integrate EHR and genetic data from multiple sites to perform pleiotropy analysis. Sum-Share requires only summary-level data and one round of communication from each site, yet it produces identical test statistics compared with that of pooled individual-level data. Consequently, Sum-Share can achieve lossless integration of multiple datasets. Using real EHR data from eMERGE, Sum-Share is able to identify 1734 potential pleiotropic SNPs for five cardiovascular diseases.”  MORE

Image Credit:  Nature.com and Penn Medicine