Signaling events and-cellular effects induced by-AngII via AT1R

It is now well established that SARS-CoV-2 targets the human ACE2 receptor to enter cells and result in COVID-19.  But some afflicted patients have an unusual immune reaction that others do not.  This is the cytokine storm.  Researchers at Hokkaido University propose they have found the trigger for crucial release.  They say:  “. . . the potential dysregulation of the AngII AT1R pathway downstream of ACE2 could lead to cytokine release syndrome as observed in COVID-19 patients that may require targeting of cytokine pathways, particularly IL-6-STAT3 axis>”  MORE

Image Credit:  ResearchGate.net