AI Aids Automatic Molecular Imaging
Japanese scientists have used fluorescent labeling microscopy and artificial intelligence to identify and locate single molecules in living cells. “. . . the apparatus is applied for single-molecule imaging and analysis of epidermal growth factor receptors (EGFRs) in 1600 cells in a 96-well plate within 1 day. Changes in the lateral mobility of EGFRs on the plasma membrane in response to various ligands and drug concentrations are clearly detected in individual cells, and several dynamic and pharmacological parameters are determined, including the diffusion coefficient, oligomer size, and half-maximal effective concentration (EC50).” While this piece specifies EGFR, hundreds of thousands of other molecules could be tracked in the same way–automatically. MORE
Image Credit: Research Director: Dr.Toshio Yanagida, Biomotron Project, Osaka