Chiral cell sliding drives left-right asymmetric organ twisting

Developmental biologists at Osaka University recently announced an important finding relative to organ regeneration: “Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we identified ‘cell sliding,’ a novel mechanism driving epithelial morphogenesis, in which cells directionally change their position relative to their subjacent (posterior) neighbors by sliding in one direction.” And, “Cell sliding may prove to be a common way to shape organs, many of which feature non-symmetrical twisted tubes of cells. In the future, learning how to control cell sliding could help researchers to create organs and biological structures in the laboratory that could be used in organ transplants and regenerative medicine.”  This discovery is particularly relevant to kidney regeneration. MORE

Image Credit: Pub Med, Osaka University