DNA Methylation in Pediatric Bone Cancer
March 14, 2017 | Terry Sharrer
A prevailing theory in cancers’ origins is that, over time, cells accumulate enough DNA damage that result in uncontrolled proliferation, invasion and immune response evasion. This report from a group of European researchers shows that in cases of Ewing sarcoma—a pediatric bone cancer—there is one common mutation (a gene fusion) but hardly any others. Rather, Ewing sarcomas present widespread epigenetic heterogeneity mostly involving DNA methylation. MORE
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