Computer Assisted Design for Nano Drug Delivery
Cell surfaces “flutter” to thermal fluxuations, according to researchers in this piece. And, that undulation influences how well a nano drug delivery device adheres to the surface. To model that situation, bioengineers at the University of Pennsylvania have created a computer program which portrays “different cell types have[ing] differing amounts of this excess membrane area and that this mechanical parameter governs how well nanocarriers can bind to the cell. Accounting for the fluttering of the membrane in their computer models, in addition to the quantity of targeting molecules on the nanocarrier and biomarkers on the cell surface, has highlighted the importance of these mechanical aspects in how efficiently nanocarriers can deliver their payloads.” MORE
Image Credit: UPenn and MDTMag.com