Wnt Signaling Pathway

In experiments with mice, Japanese scientists (RIKEN) have taken cells from mice gums and induced them to become pluripotent stem cells. Then, in tissue culture, they grew these cells into an embryoid body, which was then implanted in immune deficient mice. After a growth period in vivo, which allowed the embryoid to develop hair follicle and sebaceous gland nodes, they transplanted the skin onto normal mice and observed normal development and function restored. An important step was in adding Wnt10b molecules into the tissue culture which promoted adepogenesis and blood vessel formation. MORE

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