Proteomic Pathways to Huntington’s Disease
January 5, 2016 | Terry Sharrer
The inherited genetic pathology of Huntington’s disease has been known for more than 20 years: in the first exon of the Huntingtin gene on Chromosome 4, there occurs an excessive number of trinucleotide (CAG) repeats that result in an elongated protein which harms neurons. Recently, however, researchers at the University of Florida found that four additional proteins, without an apparent DNA signal for their translation, are implicated in Huntington’s. MORE