Stem Cell

The first hematopoietic stem cell isolator-Baxter’s Isolex machine-targeted CD34+ cells with a mouse monoclonal antibody Johns Hopkins University oncologist Curt Civin discovered in the late 1970’s. Since then, researchers have wondered if most CD34+ cells were lineage-restricted progenitors and that other cell types were truly hematopietic “grand mother” cells.  Now, researchers at the Ontario Cancer Center believe they have identified the original pluripotent HSC, which they identified as CD49f.  MORE

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Team claims both Th1+ and Thy1- stem cells expressing CD49f are capable of long-term, multilineage engraftment in xenograft mouse models.

Image Credit: Yang MingQi – Fotolia.com and Genetic Engineeing and Biotechnology News