Structural basis for mismatch surveillance by CRISPR–Cas9
“Here we [researchers at the University of Texas at Austin] used kinetics-guided cryo-electron microscopy [MORE]
How long doe gene editing last?
“. . . Intellia [Cambridge, MA] is presenting additional data from the phase 1 trial [MORE]
Gene Editing of Endothelial Cells
“To target endothelium for robust genome editing, we developed poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG-b-PLGA) copolymer-based nanoparticle [MORE]
DeepMind’s AI can predict protein shapes
Last December, Science named artificial intelligence software that calculates the shape of proteins as “the [MORE]
RNA-responsive elements for eukaryotic translational control
In this piece, researchers at the Wyss Institute “. . . introduce eukaryotic toehold switches [MORE]
New Gene Editing Proteins Found Outside of CRISPR Systems
“Scientists at MIT’s McGovern Institute and the Broad Institute of MIT and [MORE]
Engineered miniature CRISPR-Cas system
Stanford bioengineers report: “we create an efficient miniature Cas system (CasMINI) engineered from the type V-F Cas12f [MORE]
Implant scaffold with engineered cells release drug to treat inflammation
Building on their work with anti-inflammatory cartilage cells, researchers at Washington [MORE]
CRISPR therapy for rare blood diseases
“Back in 2019 the first CRISPR human clinical trials kicked off in the United States. [MORE]
Evaluating CRISPR-based prime editing for cancer modeling
“Prime editing is a recently reported genome editing tool using a nickase-cas9 fused to [MORE]
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
“Transthyretin amyloidosis . . . is a life-threatening disease characterized by progressive accumulation [MORE]
Gene-editing tool “sneaks” DNA into cells without cuts
“Researchers [Wyss Institute] have created a new gene editing tool called Retron Library [MORE]
CRISPR Off On switch
MIT and University of California at San Francisco have developed a process that better controls CRISPR gene [MORE]
Spherical liposomes are light activated for CRISPR gene therapy
Because liposomes are considered safer than viral vectors for gene delivery, researchers [MORE]