New Atlas of Rare Stem and Progenitor Cells reveals new cell types

“To create the atlas, the team [Cincinnati Children’s Hospital, et al] built detailed genomic and proteomic profiles of more than 300,000 bone marrow cells collected from a diverse mix of donors spanning ethnicity and sex. They created a new mix of 132 antibodies to probe the surface of stem and progenitor cells which helped them profile the bone marrow cell clusters. To create the finished atlas, they relied on their earlier work creating an informatics workflow that uses game theory in order to perform statistical analyses to figure out what the best cells clusters are. During the course of developing and testing their new atlas, they identified more than 89 distinct subsets of stem and progenitor cells, revealing new and rare populations.       MORE

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