Microgels in Islet Transplantation
January 10, 2023 | Terry Sharrer
“We [transplant scientists at Harvard, Georgia Tech and the University of Missouri] report a strategy through which cotransplantation of allogeneic islets and streptavidin (SA)–FasL–presenting microgels to the omentum under transient rapamycin monotherapy resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates for >6 months. Surgical extraction of the graft resulted in prompt hyperglycemia.” MORE
Image Credit: Science.org
Key words: diabetes, islet transplantation FasL-presenting microgels, rapamycin, immune tolerance promoter, Harvard University, Georgia Tech, University of Missouri