Rapid iPSC-CM Maturation on Surfaces Mimicking Native Cardiac Microenvironment
November 1, 2022 | Terry Sharrer
“Here, we [biomedical engineers at the University of Connecticut] present a method to accelerate hiPSC-CM [cardiac myocytes] maturation on a substrate, cardiac mimetic matrix (CMM), mimicking adult human heart matrix ligand chemistry, rigidity, and submicron ultrastructure, which synergistically mature hiPSC-CMs rapidly within 30 days. hiPSC-CMs matured on CMM exhibit systemic transcriptomic maturation toward an adult heart state, are aligned with high strain energy, metabolically rely on oxidative phosphorylation and fatty acid oxidation, and display enhanced redox handling capability, efficient calcium handling, and electrophysiological features of ventricular myocytes.” MORE
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