Genome Editing with IscB-ωRNA
August 9, 2022 | Terry Sharrer
“In new research, Cornell scientists provide an explanation for how this problem [i.e. the large size of Cas9 fitting into viral vectors] is solved by nature: they define with atomic precision how a transposon-derived system edits DNA in RNA-guided fashion. Transposons are mobile genetic elements inside bacteria. A lineage of transposon encodes IscB [i.e. Insertion sequences Cas9-like Bacteria], which is less than half the size of Cas9 but equally capable of DNA editing. Replacing Cas9 with IscB would definitively solve the size problem.” MORE
Image Credit: news.cornell.edu