Superresolution Imaging of Malignant Growth
May 24, 2022 | Terry Sharrer

Chromatin in cancer pathogenesis
“Stochastic optical reconstruction microscopy (STORM) is a powerful superresolution imaging technique to visualize nanoscale molecular organization down to the resolution of ~20 to 30 nm. . . . We [at the University of Pittsburgh and Vanderbilt University] developed a fast, simple, and robust small-molecule fluorescent probe—cyanine 5–conjugated Hoechst—for routine superresolution imaging of nanoscale nuclear architecture on clinical tissue. We demonstrated the biological and clinical significance of imaging superresolved chromatin structure in cancer development and its potential clinical utility for cancer risk stratification.” MORE
Image Credit: Science.org