Sonogenetic Control of Mammalian Cells (Mice)
May 3, 2022 | Terry Sharrer
Neurobiologists at the University of California, San Diego and at the Salk Institute have identified a “human Transient Receptor Potential A1 (hsTRPA1) as a candidate that confers ultrasound sensitivity to mammalian cells. Ultrasound-evoked gating of hsTRPA1 specifically requires its N-terminal tip region and cholesterol interactions; and target cells with an intact actin cytoskeleton, revealing elements of the sonogenetic mechanism. Next, we use calcium imaging and electrophysiology to show that hsTRPA1 potentiates ultrasound-evoked responses in primary neurons.” MORE
Image Credit: Nature.com